Question 1 - SIU Kidney Cancer Quiz

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Level: Moderate

QUESTION 1:
Which of the following small molecule inhibitors is matched correctly with its target(s)?

a) Belzutifan – HIF1b b) Everolimus – PDGFR c) Cabozantinib – MET, Axl, VEGFRs d) Lenvatinib – mTOR e) Tivozanib – FGFR, VEGFRs

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Incorrect, the correct answer is c

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Level: Moderate

QUESTION 2:
Which patient subset had the highest benefit in disease-free survival (DFS) from KEYNOTE-564 of adjuvant pembrolizumab versus placebo?

a) None of these options b) Tx N+ M0 c) T3/T4 N0 M0, any grade d) M1 NED e) T2 N0 M0, grade 4 or sarcomatoid

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Incorrect, the correct answer is d

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Level: Moderate

QUESTION 3:
For immunotherapy refractory metastatic clear cell renal cell carcinoma, which of the following remains the preferred treatment based on randomized phase 3 data?

a) Cabozantinib b) Lenvatinib-pembrolizumab c) Axitinib-pembrolizumab d) Cabozantinib-nivolumab e) Cabozantinib-atezolizumab

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Incorrect, the correct answer is a

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Level: Moderate

QUESTION 4:
A patient with metastatic renal cell carcinoma is being treated with axitinib and pembrolizumab. He calls with new onset diarrhea 5-6 times over the past 24h. What is the usual first step in management?

a) Start IV solumedrol 1mg/kg b) Start diphenoxylate and atropine c) Start oral prednisone 1mg/kg d) Start loperamide e) Stop axitinib

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Incorrect, the correct answer is e

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Level: Moderate

QUESTION 5:
Which of the following is the preferred first-line treatment for metastatic papillary renal cell carcinoma?

a) Sunitinib b) Lenvatinib with pembrolizumab c) Cabozantinib d) Cabozantinib with atezolizumab e) Lenvatinib with everolimus

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Incorrect, the correct answer is c

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Level: Moderate

QUESTION 1:Which of the following small molecule inhibitors is matched correctly with its target(s)?

Level: Moderate

QUESTION 2:Which patient subset had the highest benefit in disease-free survival (DFS) from KEYNOTE-564 of adjuvant pembrolizumab versus placebo?

Level: Moderate

QUESTION 3:For immunotherapy refractory metastatic clear cell renal cell carcinoma, which of the following remains the preferred treatment based on randomized phase 3 data?

Level: Moderate

QUESTION 4:A patient with metastatic renal cell carcinoma is being treated with axitinib and pembrolizumab. He calls with new onset diarrhea 5-6 times over the past 24h. What is the usual first step in management?

Level: Moderate

QUESTION 5:Which of the following is the preferred first-line treatment for metastatic papillary renal cell carcinoma?

QUESTION 1:
Which of the following small molecule inhibitors is matched correctly with its target(s)?

QUESTION 2:
Which patient subset had the highest benefit in disease-free survival (DFS) from KEYNOTE-564 of adjuvant pembrolizumab versus placebo?

QUESTION 3:
For immunotherapy refractory metastatic clear cell renal cell carcinoma, which of the following remains the preferred treatment based on randomized phase 3 data?

QUESTION 4:
A patient with metastatic renal cell carcinoma is being treated with axitinib and pembrolizumab. He calls with new onset diarrhea 5-6 times over the past 24h. What is the usual first step in management?

QUESTION 5:
Which of the following is the preferred first-line treatment for metastatic papillary renal cell carcinoma?